Heppoko Jikken Animation Excel♥Saga

Hyperactive Excel does anything and everything to try to please her lord, Ilpalazzo, who wants to take over the planet. Excel's misadventures takes her and her partner, the ever-dying Hyatt, all over the world, meeting several strange people as they go. Everything is bizarre and goofy, as any kind of anime or entertainment genre gets mocked and spoofed.

(Source: Anime News Network)